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The "novelty concept" of atrial natriuretic factor (ANF) and its plasmin-induced fragment Nt-ANF (1-29). The "novelty concept" of atrial natriuretic factor (ANF) and its plasmin-induced fragment Nt-ANF (1-29) is based on the following considerations: 1. The natriuretic effect of ANF depends on the presence of intact 28 amino acids [amino acids (aa) 22-49] and is much greater than that of its truncated fragments Nt-ANF (1-22) and Nt-ANF (1-29). 2. The natriuretic effect of Nt-ANF (1-29) is equivalent to that of ANF and increases only slightly with prolonged incubation. 3. ANF causes cGMP accumulation in bovine endothelial cells. 4. Nt-ANF (1-29) also causes cGMP accumulation and is the most potent "ANF-like" natriuretic peptide isolated so far. 5. Nt-ANF (1-29) does not inhibit the enzymatic activity of ANF-converting enzyme. 6. The "new" Nt-ANF (1-29) would have a biological activity of its own.Donald J. Trump, at a rally in San Jose on Tuesday, said he would consider temporarily banning Muslims from entering the United States. Mr. Trump made the remarks in response to a question from a woman in the audience who asked if Mr. Trump would consider banning people who support the Islamic State from entering the country. Mr. Trump later tweeted that his policy would be "total and complete shutdown of Muslims entering the United States." The proposal he made on Tuesday would apply only to immigration, not to existing visas or travel, although at least one of his Republican rivals said it should apply to all visas, not just Muslim ones.Letter Carriers Throw Paint In Illegal House's Face HUNTSVILLE, AL (WAFF) - A "happy face" made of pink paint was knocked off of a home in Huntsville Monday, but the culprits weren't just any family. "It happened at a house in which we have a Code Enforcement Officer. He was at the residence earlier today," said Huntsville Code Enforcement Office Blan Mathis

 

 

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